Gut Microbiota and Obesity-Induced Inflammation: Men’s Health Month Edition

Anne Mercer Larson, June 13, 2016

Since June is Men’s Health Month, it is a great time to take a closer look at one of the hidden ways obesity causes disease: obesity-induced inflammation. As the name implies, obesity-induced inflammation is an inflammatory state not caused by an infection, but instead caused by excess stores of body fat.

Obesity-induced inflammation complicates virtually every inflammatory disease in some way, including type 2 diabetes, atherosclerosis, certain cancers and Alzheimer’s disease.1,2,3 Fortunately, the key to fighting obesity-induced inflammation is to enlist the help of trillions of tiny soldiers: the microorganisms that make up your gut microbiota.

Fat Causes Inflammation: Obesity-Induced Inflammation

Fat stores and inflammation go hand-in-hand. Simply carrying fat stores on the body causes a low-grade inflammation.4 The more fat a person stores on the body, the greater the degree of chronic inflammation. This inflammation takes a toll on the body, resulting in various metabolic diseases and inflammatory diseases. Of course, fat loss can reduce obesity-induced inflammation5; but weight loss is difficult for many people.

CDC Time to Scale Back

8 Ways Men Can Avoid Obesity-Induced Inflammation

Men who follow these wellness tips support their personal health and may reduce the risk and severity of obesity-induced inflammation.

Make a short list of small steps (reminders in your iPhone can work) that you are willing to take in order to be in control of a better life for yourself:

    • Maintain a healthy weight — avoiding obesity is easier than losing weight. Most diets fail because you focus on depriving yourself.  Try making small but doable choices for one day. For instance, choose to drink one bottle of water in place of one of your usual soft drinks.  After a week of making that small exchange daily, you will have avoided 1,232 calories (based on one 16 oz sugar cola each day), not to mention chemicals and sugar harmful to your gut! If you make this one small exchange every day for a year, you will have avoided 64,064 calories—Wow!

 

    • Eat lean protein, vegetables, fruits, whole grains, and low-/nonfat yogurt— once again, just make one exchange choice per day for a week and pay attention to how that agrees with you. One example would be to substitute iceberg lettuce instead of a bun to hold your favorite cheeseburger. Many restaurants now offer the option.  And guess what? The final score is: Bun 120 and iceberg lettuce 0 calories. How cool is that?

 

    • Get regular exercise — moving the body burns excess calories. How many times have we all heard that? How many unused gym memberships have you paid for? Or is the exercise equipment at home collecting dust or now serving as a clothes rack?  For one week just do one thing you don’t normally do, such as parking a distance away from your office building or grocery store entrance and walking. You will feel better and burn a few calories. Increased circulation is important for your brain, heart and entire microbiome. They will thank you by giving you their best efforts back to you!

 

    • Stop smoking — better yet, never start! Ok, so this is another “no brainer.”  There is absolutely nothing good about smoking, and we all know it: lung cancer, heart disease, stroke, increased lung infections and lost work days. But what about the everyday issues? Smelly skin and clothes, secondhand smoke to your colleagues and loved ones. The cost? Depending on what state you live in, one pack a day could cost you $14 (NYC) or $98 per week, which is $5,096 for a year. In ten years, $50,960!  Invested, even conservatively, this could be your down payment on a house, a big win for your retirement plan or your kids’ college funds!!  And your body will thank you by giving you more energy, as your microbiome busily does what it’s designed to, instead of fighting off toxins and resulting mutant cells, like cancer.

 

    • Avoid binge drinking — a little alcohol is okay, but moderation is key. Do you overdo it? It’s very easy to start looking forward to crashing after a hard day or week.  So, if you think you might be going overboard, try making a small change.  Before having that first beer, martini or glass of wine, agree with yourself to drink a 16 oz bottle of water. The following week, continue your ritual with water and add a healthy fresh veggie appetizer, which will add filling fiber. Sometimes you want to drink simply because your blood sugar has dipped in the afternoon and evening before dinnerAlcohol is basically sugar.  You will feel better and save both calories and money if you make this exchange a regular habit!

 

    • Rest your body — sleep is mandatory, not optional.  Your body needs 7-8 hours to rest and repair itself. Sleep time is when cells regenerate and help you recover from wounds or illness. And, incredibly after a good night’s sleep you may save 300 calories the next day.  Obesity has been definitely linked to poor sleep. Did you know that your blood pressure drops too while you’re sleeping? And your brain power is sharper the next day. Remember that 70 to 80% of your entire immune system makes its home in your gut. Your microbiome will thank you for getting the rest it needs to repair and nourish your entire body.

 

    • Effectively manage stress — not all stress is a bad thing.  Without any, we wouldn’t be alerted to danger or get that important project finished on time. But if you find yourself snapping at coworkers or your loved ones, that’s one indication that you are in “distress.”  Try making a small but effective change in your work day. Every 30 to 45 minutes, stand up and stretch and take a few deep breaths. Even better if you can do this while looking out a window or at a favorite  wall painting or a framed photo of your loved ones. Do this every day for a week. Guaranteed to make you and your gut feel much better!

 

  • Maintain GI health — a healthy gut is probably the most direct way to reduce obesity-related inflammation. Implementing substitutions, exchanges and additions in small increments on a daily basis will make the trillions of microbes in your gut very, very happy and productive.  Your microbes have important jobs, just as you do.  Their assigned work affects every single function in this “one and only” body you’ve been given.  Like any employee, they will respond positively to better working conditions!

 

Obesity and the Microbiome

The microorganisms that live within your gut — the microbiome — play an important role in obesity-induced inflammation.6 One of the key links between obesity and the microbiome appears to be short-chain fatty acids (SCFA).7 Helpful intestinal bacteria ferment the dietary fibers you eat to produce SCFAs.8 People with intestinal diseases such ulcerative colitis have low levels of SCFA. A similar situation occurs in obesity. Obese individuals have fundamentally different microbiomes than lean individuals, with lower SCFA levels.9 When the level of SCFAs is restored, inflammation in the gastrointestinal tract is reduced.7,10

Are Prebiotics a Potential Cure for Obesity-Induced Inflammation?

Fortunately, there is a simple way to get more SCFAs: take prebiotics. After all, SCFAs are simply the product of helpful bacteria fermenting indigestible fibers such as inulin and oligofructose (i.e., prebiotics).2 By giving bacteria in the gut a different diet of insoluble fibers, the SCFA-producing bacteria will flourish and produce even greater amounts of SCFA, or so the science suggests. Considering the many desirable benefits of prebiotics for obesity and the microbiome — and their excellent safety profile — anyone with metabolic syndrome or obesity-induced inflammation should seriously consider prebiotic supplementation.

Making Men’s Health Month Count

If you are already following the 8 health tips listed above, good for you! If not, why not make Men’s Health Month your reason for taking charge of your health?

Exercise and changes to your diet will take some time to produce results, but getting a good night’s sleep can help tomorrow. Changing your drinking and smoking habits can be hard, maybe even hard enough that professional help is required. But, your rewards will far outweigh the continued penalties to your body, your family and even your bank account!  Hmmm. Rewards vs Penalties…

On the other hand, taking prebiotics couldn’t be easier and can positively change your gut microbiota within as little as two weeks.11 Many Prebiotin devotees report having increased energy, and reduced cravings for less healthy food and drink and just naturally begin choosing the right things.

Reward yourself today by ordering Prebiotin —The Most Medically Researched and Trusted #1 Doctor-Recommended Prebiotic Formula

 

For a Lifetime of Great Gut Health—Just Feed It!

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References

  1. Luchsinger JA, Gustafson DR. Adiposity, type 2 diabetes, and Alzheimer’s disease. J Alzheimers Dis. 2009;16(4):693-704. doi:10.3233/jad-2009-1022
  2. Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol. Dec 2008;8(12):923-934. doi:10.1038/nri2449
  3. Vandanmagsar B, Youm Y-H, Ravussin A, et al. The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance. Nature medicine. 2011;17(2):179-188. doi:10.1038/nm.2279
  4. Teng K-T, Chang C-Y, Chang LF, Nesaretnam K. Modulation of obesity-induced inflammation by dietary fats: mechanisms and clinical evidence. Nutrition Journal. 2014;13:12-12. doi:10.1186/1475-2891-13-12
  5. Jellema A, Plat J, Mensink RP. Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state. Eur J Clin Invest. Nov 2004;34(11):766-773. doi:10.1111/j.1365-2362.2004.01414.x
  6. Hartstra AV, Bouter KEC, Bäckhed F, Nieuwdorp M. Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes. Diabetes Care. 2015-01-01 00:00:00 2015;38(1):159-165. doi:10.2337/dc14-0769
  7. den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud D-J, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research. 2013;54(9):2325-2340. doi:10.1194/jlr.R036012
  8. Cummings JH. Short chain fatty acids in the human colon. Gut. 1981;22(9):763.
  9. Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A. 2005;102(31):11070-11075.
  10. Scheppach W, Sommer H, Kirchner T, et al. Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterology. 1992;103(1):51-56.
  11. Kellow NJ, Coughlan MT, Reid CM. Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials. Br J Nutr. Apr 14 2014;111(7):1147-1161. doi:10.1017/s0007114513003607
  12. http://www.calorieking.com/foods/calories-in-fresh-or-dried-vegetables-iceberg-lettuce-raw_f-ZmlkPTcwODk2.html
  13. http://www.webmd.com/balance/stress-management/default.htm
  14. http://www.webmd.com/sleep-disorders/default.htm

 

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